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Hi AI Futurists,

This week, OpenAI launched the Codex app—a powerful command center for building with agents. As the focus of AI moves more toward autonomous agents, Codex is OpenAI's response to Anthropic's "Claude Code," which has been gaining significant traction to start the year. How does this affect the AI landscape? Let’s take a look.

Here’s our agenda.

  • Our partner: descope

  • Top AI news

  • OpenAI fights back

  • Top 3 selected AI tools

  • AI in the wild

  • AI Investment Report

Best,
Lex Sokolin

P.S. We just released our premium AI encyclopedia report. Be sure to check it out.

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Top AI news

🧬 MIT News: Using AI to Accelerate Discovery of Therapeutic Drugs – Generative AI designs millions of antibiotic candidates, seven show real antibacterial activity

📈 Bloomberg: AMD Outlook as Investors Seek AI Payoff – Data center segment hits record $5.4B, up 39% year over year

💻 TechCrunch: Agentic Coding Comes to Apple's Xcode – Claude and Codex agents can now build, test, and fix apps autonomously

🤖 CBS News: Boston Dynamics' AI-Powered Humanoid Learning Factory Work – Atlas practices sorting parts at Hyundai's Georgia plant on 60 Minutes

🧬 Nature: Advancing Regulatory Variant Effect Prediction with AlphaGenome – DeepMind's model predicts DNA function at single-base resolution across the full genome

🔬 Science: DeepMind's Latest AI Makes Sense of Changes in Human Genome – AlphaGenome outperformed 24 of 26 models at predicting variant effects

💰 Bloomberg: TSMC's Strong Outlook Fires Up Hopes of Sustained AI Boom – $56B capex planned, ~30% revenue growth forecast for 2026

⚛️ IBM: Quantum Advantage Era – IBM predicts first verified quantum advantages by end of 2026

🧪 Nature: AI Has Designed Thousands of Potential Antibiotics – Machine learning accelerates antibiotic discovery to combat resistance

📊 Bloomberg: 2026 Investment Outlooks – AI called "the defining theme for equity markets" across 60+ institutions

OpenAI fights back

OpenAI just launched a new Codex desktop app, a major push to put code generation tools directly in front of developers and technical professionals. The standalone app is designed for speed, offline functionality, and tight OS-level integration — including native keyboard shortcuts and an always-on assistant feel. OpenAI is clearly going after the domain of local developer tools, with some comparing this move to Apple’s early software playbook. The app’s release marks a shift away from browser-based tools, with OpenAI betting that a desktop-first experience will improve adoption among power users.

Unlike ChatGPT, which remains general-purpose, Codex is aimed squarely at programmers, technical PMs, and power users. OpenAI says it’s targeting "real productivity" by embedding the assistant deeply into the dev workflow. It runs GPT-4-turbo and is fine-tuned for tasks like writing, editing, and explaining code, along with command-line interactions. The app feels more like a fusion of GitHub Copilot and Spotlight Search, enabling users to launch code snippets or refactor entire files instantly. According to OpenAI's Logan Kilpatrick, the goal is to create “a developer-native experience that feels like magic but works like a tool.”

You can read more here on OpenAI, here via Yahoo Finance, or check out the deep dive from Ars Technica. This also ramps up the race against Anthropic’s Claude and others, as OpenAI looks to re-establish technical dominance in day-to-day dev environments. The line between “copilot” and “coder” continues to blur — and for humans, the real edge is shifting toward judgment, architecture, and taste.

Takeaways at a Glance:

  • Codex app runs GPT-4-turbo fine-tuned for dev tasks

  • Deep OS-level integration: keyboard-first, offline-friendly

  • Targets devs, PMs, and power users for code generation and refactoring

  • Always-on assistant approach, positioned as a rival to Claude and Copilot

  • Plays into OpenAI’s strategy to win on tools, not just models


What We Think About It:

  • This is OpenAI’s strongest move yet to live inside a dev's stack, not just their browser. It could reshape the way power users build and run code day-to-day. Claude may outperform in reasoning, but Codex is now winning on real-world interface and speed.

What You Can Do Right Now:

  • Try out the Codex app by downloading it to your computer (currently Mac only), exploring what it can do, and seeing how it fits into your daily tech or coding tasks. If you already use tools like Copilot or ChatGPT, compare them and see which one feels more helpful.

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AI In the Wild

AI Investment Report

This 158-page research report provides the first comprehensive taxonomy of public companies, private ventures, and tokenized protocols building the infrastructure for autonomous AI systems. Compiled by Lex Sokolin, former Chief Economist at ConsenSys, fintech strategist at Autonomous Research, and current Managing Partner at Generative Ventures, this report delivers institutional-grade analysis of 100+ companies across 14 critical infrastructure layers. Learn more here.

AI & Robotics Industry Encyclopedia

AI & Robotics Industry Encyclopedia

In this 158 page report, we collate all the meaningful companies across public equities, private equity, and digital assets related to the machine economy. There are 13 sections of company types, a...

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